About 5-MeO-MIPT Powder in USA
About 5-MeO-MIPT Powder in USA, 5-Methoxy-N-methyl-N-isopropyltryptamine (also known as 5-MeO-MiPT and moxy) is a lesser-known psychedelic substance of the tryptamine class. First, 5-MeO-MiPT is chemically related to tryptamines like 5-MeO-DMT and 5-MeO-DiPT. Second, It produces its psychoactive effects through activity at serotonin receptors in the brain.
And, The synthesis and pharmacology of 5-MeO-MiPT was first reported in 1985 by David Repke and Alexander Shulgin. In addition to, Its effects in humans was documented in Shulgin’s book TiHKAL (“Tryptamines I Have Known and Loved”).
Anecdotal reports describe 5-MeO-MiPT’s effects as highly stimulating and mildly entactogenic, lacking in typical psychedelic visual distortions. Furthermore, Many users report strong physical and tactile effects that serve to enhance libido and sexual pleasure. Moreover, An unpleasant “body load” is also often reported at common to high doses, marked by muscle tension and nausea.
Not only-but also, Very little is known about the pharmacological properties, metabolism and toxicity of 5-MeO-MiPT, and it has a limited history of human use. Besides, It has been sold online as a research chemical. As a result, It is highly advised to use harm reduction practices when using this substance.
Contents
1 Chemistry
2 Pharmacology
[+]3 Subjective effects
4 Reagent results
[+]5 Toxicity and harm potential
6 Legal status
7 See also
[+]8 External links
9 References
Chemistry
5-MeO-MiPT, or 5-methoxy-N-methyl-N-isopropyltryptamine, is a synthetic indole alkaloid molecule of the tryptamine class. Tryptamines share a core structure comprised of a bicylic indole heterocycle attached at R3 to an amino group via an ethyl side chain. 5-MeO-MiPT is substituted at R5 of its indole heterocycle with a methoxy (MeO) functional group CH3O−; it also contains a methyl group and an isopropyl chain bound to the terminal amine RN of its tryptamine backbone (MiPT).
5-MeO-MiPT is the N-substituted isopropyl homologue of 5-MeO-DMT.[2]
Pharmacology
Further information: Serotonergic psychedelic
5-MeO-MiPT’s psychedelic effects are believed to come from its efficacy at the 5-HT2A receptor as a partial agonist[3][1] and additional mechanisms of action such as the inhibition of MAO (i.e. digestive enzymes in the stomach) have also been speculated upon, though this has yet to be demonstrated scientifically. While 5-MeO-MiPT binds most strongly to 5-HT1A receptors, it also shows fairly strong binding affinity to the SERT and NET, thereby acting as a moderately potent serotonin-norepinephrine reuptake inhibitor.[4] These mechanisms may help explain why there are many anecdotal reports of anti-depressant and anxiolytic effects from modest doses of this compound. For example, SNRIs such as venlafaxine are commonly prescribed to treat depression, and the 5-HT1A agonist buspirone is prescribed primarily for treatment of anxiety.
Subjective effects
5-MeO-MiPT can be taken via oral ingestion or it can be smoked. When ingested orally, the visual and sensory effects are reported to become more prominent. The experience can be broken up into two stages; the first half feels stimulating and entactogenic whilst the second half feels more similar to a traditional tryptamine psychedelic like psilocybin mushrooms or LSD. When smoked, the physically and cognitively stimulating effects become emphasized.
Disclaimer: The effects listed below cite the Subjective Effect Index (SEI), an open research literature based on anecdotal user reports and the personal analyses of PsychonautWiki contributors. As a result, they should be viewed with a healthy degree of skepticism.
It is also worth noting that these effects will not necessarily occur in a predictable or reliable manner, although higher doses are more liable to induce the full spectrum of effects. Likewise, adverse effects become increasingly likely with higher doses and may include addiction, severe injury, or death ☠.
Physical effectsChild.svg
Stimulation – At doses below 10 to 15mg, 5-MeO-MiPT produces a degree of stimulation comparable to that of LSD.
Spontaneous bodily sensations – The “body high” of 5-MeO-MiPT can be described as a pleasurable, warm, soft and all-encompassing glow. This may be accompanied by a cold, sharp tingling sensation that manifests spontaneously at different unpredictable points throughout the experience, although for others can maintain a consistent presence that steadily rises with the onset and hits its limit once the peak has been reached.
Nausea – Nausea is commonly reported and can sometimes result in vomiting, although it typically fades after the come up phase. In comparison to 5-MeO-DiPT, this substance has a much lower tendency to trigger unpleasant physical reactions.
Bodily pressures
Abnormal heartbeat[citation needed]
Increased heart rate[citation needed]
Increased blood pressure[citation needed]
Headaches[citation needed]
Dehydration
Stomach bloating – At higher doses, this compound can induce severe stomach bloating within those who are susceptible. This can be partially to fully mitigated through the use of antacids.
Pupil dilation
Vasoconstriction
Diarrhea
Visual effects Eye. svg
Enhancements
Colour enhancement
Pattern recognition enhancement
Visual acuity enhancement
Distortions
Drifting (Melting, Breathing, Warping and Flowing) – In comparison to other psychedelics, this effect can be described as highly detailed, slow and smooth in motion and static in appearance.
Tracers
After images
Symmetrical texture repetition
Colour shifting
Scenery slicing
Geometry
The visual geometry produced by 5-MeO-MiPT can be described as more similar in appearance to that of Psilocin, 4-AcO-DMT or ayahuasca than that of LSD or 2C-B. Both-and, It can be comprehensively described through its variations as intricate in complexity, abstract in form, organic in feel, brightly lit, multicoloured in scheme, glossy in shading, equal in blurred and sharp edges, large in size, fast in speed, smooth in motion, equal in rounded and angular corners, non-immersive in depth and progressive in intensity. In the second place, At higher dosages they are significantly more likely to result in states of level 8B visual geometry over level 8A.
Hallucinatory states
First, 5-MeO-MiPT produces a full range of high level hallucinatory states in a fashion that is more consistent and reproducible than that of many other commonly used psychedelics.
Transformations
Internal hallucination (autonomous entities; settings, sceneries, and landscapes; perspective hallucinations and scenarios and plots) – In comparison to other psychedelics such as LSD, 5-MeO-MiPT is extremely high in hallucinations at appropriate dosages. Moreover, These are more common in darkness and can be comprehensibly described through their variations as lucid in believability, interactive in style, new experiences in content, autonomous in controllability, geometry-based in style and almost exclusively of a personal, religious, spiritual, science-fiction, fantasy, surreal, nonsensical or transcendental nature in their overall theme.
Cognitive effects User.
At low to moderate doses, the cognitive effects of 5-MeO-MiPT are often described by many as both insightful and moderately relaxing, but at some points quite stimulating. Further, 5-MeO-MiPT produces a large number of typical psychedelic cognitive effects which progressively intensify proportional to dosage. At higher dosages, however, it becomes primarily sedating and impairing with depersonalization and no accompanying insight.
Analysis enhancement
Empathy, affection, and sociability enhancement – This effect is consistently manifested only in the context of social settings in which one is within the company of others. And, These feelings of sociability, love and empathy are a little weaker and less sharp than those found on substances such as MDMA and 2C-B but still prove strong enough to provide long-lasting therapeutic effects.
Depersonalization – Unlike most traditional psychedelics, 5-MeO-MiPT can cause extreme depersonalization and dissociation for some users throughout the duration of the experience.
Conceptual thinking
Increased music appreciation
Emotion enhancement
Increased libido
Memory suppression
Novelty enhancement
Personal bias suppression
Thought acceleration
Thought connectivity
Time distortion
Wakefulness